Periannan Kuppusamy
Appointments
Professor of Radiology
Professor of Medicine
Area of Expertise
Cancer Biology,
Pharmacology and Molecular Therapeutics
Biography
Dr. Kuppusamy’s research expertise includes detection and imaging of oxygen free radicals; myocardial ischemia-reperfusion injury; stem-cell therapy for cardiac repair; ROS pathophysiology in vascular remodeling; tumor physiology, oxygenation, and drug-resistance; small-molecule therapeutics for heart disease and cancer; technology development for noninvasive measurement of tissue oxygen levels (oximetry); molecular probes for free radical biology and medicine; EPR spectroscopy, imaging software, and instrumentation.
Dr. Kuppusamy’s current research interests include oxygen biology and oximetry. His lab is working on the effect and mechanisms of supplemental oxygenation for mitigation of hypoxia-mediated tumor aggression/metastasis and inhibition of growth. Dr. Kuppusamy’s laboratory has developed oxygen-sensing magnetic chips (OxyChip) for tissue oximetry. The patented technology is capable of noninvasive and repeated measurement of oxygen concentration (pO2) from topical (skin) to deep tissues. The OxyChip is currently under phase I clinical trial, supported by a P01 award from the National Cancer Institute.
Education
1987-90 Cardiovascular Fellowship - Johns Hopkins University
1986-87 Fogarty Fellow, National Institutes of Health
1980-85 PhD - Indian Institute of Technology (Chennai)
1975-77 MSc - University of Madras
1972-75 BSc - University of Madras
Publications
- Madan E, Pelham CJ, Nagane M, Parker TM, Canas-Marques R, Fazio K, Shaik K, Yuan Y, Henriques V, Galzerano A, Yamashita T, Pinto MAF, Palma AM, Camacho D, Vieira A, Soldini D, Nakshatri H, Post SR, Rhiner C, Yamashita H, Accardi D, Hansen LA, Carvalho C, Beltran AL, Kuppusamy P, Gogna R, Moreno E. Flower isoforms promote competitive growth in cancer. Nature. 2019 Jul 24; doi: 10.1038/s41586-019-1429-3. Epub 2019 Jul 24. PMID: 31341286
- Kmiec MM, Tse D, Mast JM, Ahmad R, Kuppusamy P. Implantable microchip containing oxygen-sensing paramagnetic crystals for long-term, repeated, and multisite in vivo oximetry. Biomedical Microdevices. 2019 Jul 8;21(3):71. doi: 10.1007/s10544-019-0421-x. Epub 2019 Jul 8. PMID: 31286244
- Mast JM, Tse D, Shee K, Lakshmi Kuppusamy M, Kmiec MM, Kalai T, Kuppusamy P. Diarylidenylpiperidones, H-4073 and HO-3867, Induce G2/M Cell-Cycle Arrest, Apoptosis and Inhibit STAT3 Phosphorylation in Human Pancreatic Cancer Cells. Cell Biochem Biophys. 2019 Jun;77(2):109-119. doi: 10.1007/s12013-019-00873-6. Epub 2019 May 14. PMID: 31089934
- Polacco MA, Hou H, Kuppusamy P, Chen EY. Measuring Flap Oxygen Using Electron Paramagnetic Resonance Oximetry. Laryngoscope. 2019 Apr 29; doi: 10.1002/lary.28043. Epub 2019 Apr 29. PMID: 31034638
- Kmiec MM, Hou H, Kuppusamy ML, Drews TM, Prabhat AM, Petryakov SV, Demidenko E, Schaner PE, Buckey JC, Blank A, Kuppusamy P. Application of SPOT chip for transcutaneous oximetry. Magn Reson Med. 2019 May;81(5):2837-2840. doi: 10.1002/mrm.27667. Epub 2019 Feb 13. PMID: 30761605
- Dayan N, Ishay Y, Artzi Y, Cristea D, Reijerse E, Kuppusamy P, Blank A. Advanced surface resonators for electron spin resonance of single microcrystals. Rev Sci Instrum. 2018 Dec;89(12):124707. doi: 10.1063/1.5063367. PMID: 30599630
- Prabhat AM, Kuppusamy ML, Bognar B, Kalai T, Hideg K, Kuppusamy P. Antiproliferative Effect of a Novel 4,4'-Disulfonyldiarylidenyl Piperidone in Human Colon Cancer Cells. Cell Biochem Biophys. 2019 Mar;77(1):61-67. doi: 10.1007/s12013-018-0862-5. Epub 2018 Dec 14. PMID: 30552554
- Mast JM, Kuppusamy P. Hyperoxygenation as a Therapeutic Supplement for Treatment of Triple Negative Breast Cancer. Front Oncol. 2018;8:527. doi: 10.3389/fonc.2018.00527. Epub 2018 Nov 20. PMID: 30524959
- Kmiec MM, Hou H, Lakshmi Kuppusamy M, Drews TM, Prabhat AM, Petryakov SV, Demidenko E, Schaner PE, Buckey JC, Blank A, Kuppusamy P. Transcutaneous oxygen measurement in humans using a paramagnetic skin adhesive film. Magn Reson Med. 2019 Feb;81(2):781-794. doi: 10.1002/mrm.27445. Epub 2018 Sep 11. PMID: 30277275
- Hou H, Khan N, Gohain S, Kuppusamy ML, and Kuppusamy P. Pre-clinical evaluation of OxyChip for long-term EPR oximetry. Biomed Microdevices 20(2): 29 (2018). PMID: 29549438
- Madan E, Parker TM, Bauer MR, Dhiman A, Pelham CJ, Nagane M, Kuppusamy ML, Holmes M, Holmes TR, Shaik K, Shee K, Kiparoidze S, Smith SD, Park YA, Gomm J, Jones LJ, Tomas AR, Cunha AC, Selvendiran K, Hansen LA, Fersht AR, Hideg K, Gogna R, Kuppusamy P. The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53. J Biol Chem, 293, 4262-4276 (2018). PMID: 29382728
- Mast JM, Kuppusamy P. Hyperoxygenation as a therapeutic supplement for treatment of triple-negative breast cancer. Frontiers in Oncology 8, 527 (2018). https://doi.org/10.3389/fonc.2018.00527
- Nagane M, Kuppusamy ML, An J, Mast JM, Gogna R, Yasui H, Yamamori T, Inanami O, Kuppusamy P. Ataxia-telangiectasia mutated (ATM) kinase regulates eNOS expression and modulates radiosensitivity in endothelial cells exposed to ionizing radiation. Radiat Res. 2018 May;189(5):519-528. doi: 10.1667/RR14781.1. Epub 2018 Feb 23. PMID: 29474156
- Zgadzai O, Twig Y, Wolfson H, Ahmad R, Kuppusamy P, Blank A. Electron-Spin-Resonance dipstick. Anal Chem. 2018 Jul 3;90(13):7830-7836. doi: 10.1021/acs.analchem.8b00917. Epub 2018 Jun 13. PMID: 29856211
- Prabhat AM, Kuppusamy ML, Naidu SK, Meduru S, Reddy PT, Dominic A, Khan M, Rivera BK, Kuppusamy P. Supplemental oxygen protects heart against acute myocardial infarction. Front Cardiovasc Med. 2018 Aug 28;5:114. doi: 10.3389/fcvm.2018.00114. PMID: 30211171
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