Topics in Advanced Biophysical Chemistry
Treatment at an advanced level of one or more areas of biophysical chemistry. The subject matter varies from offering to offering; accordingly the course may be taken for credit more than once.
161.1 Membrane Biophysics. The structure and function of cell membranes, with emphasis on the complex behavior of intrinsic membrane proteins and its relation to physical properties of the lipid bilayer.
161.2 Biomolecular Simulations. An advanced treatment of modern computational approaches to the folding, structure, and dynamics of proteins and nucleic acids and their complexes. Topics include folding, searching algorithms, homology modeling, energy landscape deformation, and multi-dimensional searching.
161.3 Biomolecular NMR. The theoretical and practical aspects of the modern use of nuclear magnetic resonance in the study of biomolecules including peptides/proteins, synthetic and natural products, and nucleic acids will be developed.
161.4 Structure and Dynamics of Biomolecules.The theoretical and practical aspects for the determination of the structure and dynamics of proteins, and nucleic acids will be developed. Particular emphasis will be placed on the utilization of X-ray diffraction, cryo-electron microscopy, and high-resolution NMR and the computational approaches associated with them.
161.5 Protein Crystallography. Theoretical aspects for the determination of protein structures using X-ray crystallography. Topics will include a detailed description of crystal symmetry, diffraction theory, data collection and processing, and methods for solving the crystallographic phase problem.