Jimmy Wu

Academic Appointments

Associate Professor of Chemistry

Connect with Us

Research in the Wu group focuses on the development of new reactions for  synthesizing compounds that have potential therapeutic value.  These include (4+3) and (3+2) cycloadditions with indole, redox chain reactions, etc.  In particular, we have identified molecules that can up-regulate the secretion of GLP-1 (glucagon-like peptide-1), inhibit the growth of MRSA, and induce apoptosis in leukemia cells.  For each of these projects, we have teamed up with biological collaborators to study mechanisms of action and identify more potent analogues.

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Contact

6128 Burke Laboratories, Hanover NH 03755
HB 6128

Education

  • A.B. Princeton University 1994-1998
  • Ph.D. Harvard University 2001-2005
  • NIH Postdoctoral Fellow Stanford University 2005-2007
  • Associate Chemist Merck Process Research 1999-2001

Selected Publications

  • “Nucleophile-intercepted Beckmann Fragmentation Reactions” Touchette, S. J.; Dunkley, E. M.; Lowder, L. L. Wu, J. Chem. Sci. 201910, 7812−7815.

  • “Nuphar Alkaloids Induce Very Rapid Apoptosis Through a Novel Caspase-Dependent but BAX/BAK-Independent Pathway” Mallick, D. J.; Korotkov, A.; Li, H.; Wu, J.; Eastman, A. Cell Bio. Toxicol. 201935, 435−443.

  • "Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space” Kearney, S. E.; Zahoránszky-Kőhalmi, G.; Brimacombe, K. R.; Henderson, M. J.; Lynch, C.; et al. ACS Cent. Sci. 20184, 1727−1741.

  • "Catalytic Vinylogous Cross-Coupling Reactions of Rhenium Vinylcarbenoids” Chen, J.; Wu, J. Chem. Sci. 20189, 2489-2492. (One of Angewandte Chemie’s Top 20 Most Downloaded recent papers)

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