Alexandre Pletnev

Research Scientist

Dr. Pletnev received his undergraduate degree in Chemistry from the Higher Chemical College of the Russian Academy of Sciences in 1996 and a Ph.D. degree in Organic Chemistry from Iowa State University in 2002. His graduate work focused on developing novel palladium-catalyzed synthetic organic methodology. He continued his studies as a postdoc at the University of California, Riverside, working on the total synthesis of Myrmicarin alkaloids. In 2005, he accepted an industrial position at Materia, Inc, where he spent two years developing ruthenium catalysts for olefin metathesis. Dr. Pletnev joined the research faculty at Dartmouth College in 2007.

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Contact

311 Burke Laboratory
HB 6128

Selected Publications

  • Belenky, P.; Christensen, K. C.; Gazzaniga, F.; Pletnev, A. A.; Brenner, C. “Nicotinamide Riboside and Nicotinic Acid Riboside Salvage in Fungi and Mammals: Quantitative Basis for Urh1 and Purine Nucleoside Phosphorylase Function in NAD+ Metabolism”, J. Biol. Chem. 2009, 284, 158-164.

  • Garner, K. M.; Pletnev, A. A.; Eastman, A. “Corrected Structure of Mirin, a Small-Molecule Inhibitor of the Mre11-Rad50-Nbs1 Complex”, Nature Chem. Biol. 2009, 5, 129-130.

  • Britton, M.; Lucas, M. M.; Downey, S. L.; Screen, M.; Pletnev, A. A.; Verdoes, M.; Tokhunts, R. A.; Amir, O.; Goddard, A. L.; Pelphrey, P. M.; Wright, D. L.; Overkleeft, H. S.; Kisselev, A. F. “Selective Inhibitor of Proteasome's Caspase-like Sites Sensitizes Cells to Specific Inhibition of Chymotrypsin-like Sites”, Chemistry & Biology 2009, 16, 1278-1289.

  • Albershardt, T. C.; Pletnev, A. A.; Eastman, A. “Most putative BH3 mimetics preferentially antagonize the anti-apoptotic protein MCL-1 rather than BCL-2”, AACR 101st Annual Meeting, Washington, DC, 2010

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