Alexandre Pletnev

Research Scientist

Dr. Pletnev received his undergraduate degree in Chemistry from the Higher Chemical College of the Russian Academy of Sciences in 1996 and a Ph.D. degree in Organic Chemistry from Iowa State University in 2002. His graduate work focused on developing novel palladium-catalyzed synthetic organic methodology. He continued his studies as a postdoc at the University of California, Riverside, working on the total synthesis of Myrmicarin alkaloids. In 2005, he accepted an industrial position at Materia, Inc, where he spent two years developing ruthenium catalysts for olefin metathesis. Dr. Pletnev joined the research faculty at Dartmouth College in 2007.

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Research Interests

I work with researchers from the Norris Cotton Cancer Center, Geisel School of Medicine and the broader Dartmouth community to help them design and execute various synthetic projects in support of their biomedical research. These projects range from developing reliable and scalable syntheses of known biologically active compounds to traditional medicinal chemistry and preparation of novel peptides and small molecules. This allows me to provide a valuable service to those who do not necessarily have experience in organic synthesis.

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311 Burke Laboratory
HB 6128

Selected publications

Belenky, P.; Christensen, K. C.; Gazzaniga, F.; Pletnev, A. A.; Brenner, C. “Nicotinamide Riboside and Nicotinic Acid Riboside Salvage in Fungi and Mammals: Quantitative Basis for Urh1 and Purine Nucleoside Phosphorylase Function in NAD+ Metabolism”, J. Biol. Chem. 2009, 284, 158-164.

Garner, K. M.; Pletnev, A. A.; Eastman, A. “Corrected Structure of Mirin, a Small-Molecule Inhibitor of the Mre11-Rad50-Nbs1 Complex”, Nature Chem. Biol. 2009, 5, 129-130.

Britton, M.; Lucas, M. M.; Downey, S. L.; Screen, M.; Pletnev, A. A.; Verdoes, M.; Tokhunts, R. A.; Amir, O.; Goddard, A. L.; Pelphrey, P. M.; Wright, D. L.; Overkleeft, H. S.; Kisselev, A. F. “Selective Inhibitor of Proteasome's Caspase-like Sites Sensitizes Cells to Specific Inhibition of Chymotrypsin-like Sites”, Chemistry & Biology 2009, 16, 1278-1289.

Albershardt, T. C.; Pletnev, A. A.; Eastman, A. “Most putative BH3 mimetics preferentially antagonize the anti-apoptotic protein MCL-1 rather than BCL-2”, AACR 101st Annual Meeting, Washington, DC, 2010

Screen, M.; Britton, M.; Downey, S. L.; Verdoes, M.; Voges, M. J.; Blom, A. E. M.; Geurink, P. P.; Risseeuw, M. D. P.; Florea, B. I.; van der Linden, W. A.; Pletnev, A. A.; Overkleeft, H. S.; Kisselev, A. F. “Nature of Pharmacophore Influences Active Site Specificity of Proteasome Inhibitors”, J. Biol. Chem. 2010, 285, 40125-40134.

 

Pound, G. J.; Pletnev, A. A.; Fang, X.; Pletneva, E. V. “A Small Fluorophore Reporter of Protein Conformation and Redox State”, Chem. Commun. 2011, 47, 5714-5716.

Mirabella, A. C.; Pletnev, A. A.; Downey, S. L.; Florea, B. I.; Shabaneh, T. B.; Britton, M.; Verdoes, M.; Filippov, D.; Overkleeft, H. S.; Kisselev, A. F. “Specific cell-permeable inhibitor of proteasome trypsin-like sites selectively sensitizes myeloma cells to bortezomib and carfilzomib”, Chemistry & Biology 2011, 18, 608-618.

Albershardt, T. C.; Salerni, B. L.; Soderquist, R. S.; Bates, D. J. P.; Pletnev, A. A.; Kisselev, A. F.; Eastman, A. “Multiple BH3 Mimetics Antagonize Anti-Apoptotic MCL1 by Inducing the Endoplasmic Reticulum Stress Response and Up-Regulating BH3-only Protein NOXA”, J. Biol. Chem. 2011, 286, 24882-24895.

 

Kettenbach, A. N.; Schweppe, D. K.; Faherty, B. K.; Pechenick, D.; Pletnev, A. A.; Gerber, S. A. “Quantitative Phosphoproteomics Identifies Novel Substrates and Functional Modules of Aurora and Polo-like Kinase Activities in Mitosis”, Sci. Signal. 2011, 4, rs5.

Soderquist, R.; Pletnev, A. A.; Danilov, A. V.; Eastman, A.”The Putative BH3 Mimetic S1 Sensitizes Leukemia to ABT-737 by Increasing Reactive Oxygen Species, Inducing Endoplasmic Reticulum Stress, and Upregulating the BH3-Only Protein NOXA”, Apoptosis 2014, 19, 201-209.

Pal, K; Pletnev, A. A.; Dutta, S. K.; Wang, E.; Zhao, R.; Baral, A.; Yadav, V. K.; Aggarwal, S.; Krishnaswamy, S.; Alkharfy, K. M.; Chowdhury, S.; Spaller, M. R.; Mukhopadhyay, D. “Inhibition of Endoglin-​GIPC Interaction Inhibits Pancreatic Cancer Cell Growth”, Mol. Cancer Ther. 201413, 2264-2275.

Weyburne, E. S.; Wilkins, O. M.; Sha, Z.; Williams, D. A.; Pletnev, A. A.; de Bruin, G.; Overkleeft, H. S.; Goldberg, A. L.; Cole, M. D.; Kisselev, A. F. “Inhibition of the Proteasome β2 Site Sensitizes Triple-​Negative Breast Cancer Cells to β5 Inhibitors and Suppresses Nrf1 Activation”, Cell Chemical Biology (2017), 24(2), 218-230.

Zhao, Y.; Cushing, P. R.; Smithson, D. C.; Pellegrini, M.; Pletnev, A. A.; Al-Ayyoubi, S.; Grassetti, A. V.; Gerber, S. A.; Guy, R. K.; Madden, D. R. “Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain”, Bioscience reports 201838, BSR20180231.

 

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