Emanuele Scalone
Appointments
Postdoc
Biography
I am a postdoctoral fellow in the Department of Chemistry at Dartmouth College and part of the Robustelli group.
I received my Ph.D. from the Department of Biosciences at the University of Milan, where I worked on developing a computational method called "multi-eGO" to study the molecular mechanisms of protein aggregation and its implications in neurodegenerative diseases. I graduated in Molecular Biotechnology and Bioinformatics (MBB) from the same university in 2018, with a thesis on the development of new drugs against protein aggregation using ALS as a model.
I also participated in some structural studies on gelsolin and XIAP, a protein involved in amyloidosis and cancer respectively. Such studies involved crystallography, computational modelling and biochemical assays.
Publications
Scalone, E., Broggini, L., Visentin, C., Erba, D., Toplek, F. B. C. C., Peqini, K., Pellegrino, S., Ricagno, S., Paissoni, C., & Camilloni, C. (2022). Multi-eGO: An in silico lens to look into protein aggregation kinetics at atomic resolution. Proceedings of the National Academy of Sciences, 119(26). https://doi.org/10.1073/PNAS.2203181119
Muzio, L., Sirtori, R., Gornati, D., Eleuteri, S., Fossaghi, A., Brancaccio, D., Manzoni, L., Ottoboni, L., Feo, L. de, Quattrini, A., Mastrangelo, E., Sorrentino, L., Scalone, E., Comi, G., Marinelli, L., Riva, N., Milani, M., Seneci, P., & Martino, G. (2020). Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis. Nature Communications, 11(1), 3848. https://doi.org/10.1038/s41467-020-17524-7
Rosa, M. de, Barbiroli, A., Bonì, F., Scalone, E., Mattioni, D., Vanoni, M. A., Patrone, M., Bollati, M., Mastrangelo, E., Giorgino, T., & Milani, M. (2019). The structure of N184K amyloidogenic variant of gelsolin highlights the role of the H-bond network for protein stability and aggregation properties. European Biophysics Journal. https://doi.org/10.1007/s00249-019-01409-9
Bollati, M., Scalone, E., Bonì, F., Mastrangelo, E., Giorgino, T., Milani, M., & Rosa, M. de. (2019). High-resolution crystal structure of gelsolin domain 2 in complex with the physiological calcium ion. Biochemical and Biophysical Research Communications, 518(1), 94–99. https://doi.org/10.1016/j.bbrc.2019.08.013
Contact