Synthesis of the Cortistatin Pentacyclic Core by Alkoxide-Directed Metallacycle-Mediated Annulative Cross-Coupling

The Micalizio laboratory has established a synthesis pathway to the pentacyclic core of the rare anticancer and antiviral cortistatins by application of their metallacycle-mediated alkoxide-directed annulative cross-coupling reaction. heir route begins with epichlorohydin, establishes the key trans-fused hydrindane in just six steps, with 9 subsequent steps being employed to establish the ABC-tricyclic system.

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