FadR is a regulator of fatty acid metabolism and influences virulence in members of the Vibrio family of enteric bacteria including the bacterium Vibrio cholerae, which is responsible for cholera infection in humans. Recent research by Wei Shi in Jon Kull’s group has shown Vibrio FadR contains an unusual C-terminal 40-amino acid insertion. This insertion allows for the binding of an additional fatty acid ligand that causes a greater conformational change to disrupt DNA binding. Structures and findings of the research were recently reported in Nature Communications.
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