Faculty Research Areas

Organic Chemistry

A marine sea slug (nudibranch) loaded with natural organohalogen compounds as antifeedants (Gordon Gribble).

A marine sea slug (nudibranch) loaded with natural organohalogen compounds as antifeedants (Gordon Gribble).

Organic chemistry research at Dartmouth includes natural products, synthetic methods, and medicinal chemistry, as well as interdisciplinary areas like asymmetric catalysis, organometallics, bioorganic chemistry, and molecular machines.

  • Ivan Aprahamian Molecular machines 
  • David S. Glueck Homogeneous catalysis, asymmetric catalysis, sustainable energy
  • Gordon W. Gribble Organic synthesis, biologically active natural products, heterocyclic chemistry 
  • Russell P. Hughes Organometallic mechanism and synthesis, CF bond activation, catalysis 
  • Chenfeng Ke  Synthesis of porous organic polymer and 3D printable polymers
  • Glenn C. Micalizio Reaction methodology/synthesis strategy, natural product synthesis, discovery-oriented synthesis
  • Peter A. Jacobi Natural product synthesis, synthetic methodology, heterocyclic chemistry 
  • Jimmy Wu Organic synthetic methodology, organocatalysis 
  • Mark Spaller (adjunct professor) organic and peptide synthesis, biochemistry, molecular biology, and biophysics 

Biological/Biophysical Chemistry

The high resolution NMR structure of the C-terminus of the glutamate receptor with PDZ1 of the molecular scaffolding protein, SAP-90 (Dale Mierke).

The high resolution NMR structure of the C-terminus of the glutamate receptor with PDZ1 of the molecular scaffolding protein, SAP-90 (Dale Mierke).

Molecular Dynamics snapshot of the neurotransmitter GABA in a lipid bilayer (Robert Cantor).

Molecular Dynamics snapshot of the neurotransmitter GABA in a lipid bilayer (Robert Cantor).

Dartmouth researchers study the structure and function of biomolecules using NMR, laser spectroscopy, X-ray crystallography, calorimetry, synthesis, and computational methods.

  • Robert S. Cantor Biophysics of cell membranes, amphiphilic aggregates in solution 
  • F. Jon Kull Protein crystallography, molecular motors, cellular transport mechanisms, enzyme mechanisms 
  • Dale F. Mierke Biophysical chemistry, high resolution NMR, peptide hormone structure and function 
  • Ekaterina V. Pletneva Bioinorganic chemistry, redox reactivity and conformational dynamics of heme proteins 
  • Michael J. Ragusa protein crystallography, small angle X-ray scattering, peripheral membrane proteins, autophagy
  • Dean E. Wilcox Bioinorganic chemistry, thermodynamics of metal-protein interactions, metalloenzymes, nitric oxide biochemistry
  • Mark Spaller (adjunct professor) organic and peptide synthesis, biochemistry, molecular biology, and biophysics 

Materials Chemistry

Structure of a magnesium zinc oxide surface (Joe BelBruno).

Structure of a magnesium zinc oxide surface (Joe BelBruno).

A helical molecular wire designed by Ivan Aprahamian.

A helical molecular wire designed by Ivan Aprahamian.

Learn about our research on polymers, sensors, surfaces, molecular machines, and nanomaterials, which uses both experimental and theoretical techniques.

  • Ivan Aprahamian Molecular machines 
  • Joseph J. BelBruno Experimental and computational study of clusters, sensors, nanomaterials 
  • David S. Glueck Homogeneous catalysis, asymmetric catalysis, sustainable energy 
  • Chenfeng Ke  3D fabrication of stimuli-responsive materials (4D printing).  Porous organic crystals for energy and water purifications
  • Jane E. G. Lipson Statistical mechanics of polymer melts, glasses, and blends.  Theory and simulation applied to problems of blend behavior, and glassy thin films and mixtures. 

Inorganic Chemistry

The π*-LUMO of the Ir-carbon double bond in a bis(trifluoromethyl)carbene complex of iridium (Russ Hughes)

The π*-LUMO of the Ir-carbon double bond in a bis(trifluoromethyl)carbene complex of iridium (Russ Hughes)

Structure of a gold phosphido complex (David Glueck).

Structure of a gold phosphido complex (David Glueck).

Dartmouth faculty specialize in bioinorganic and organometallic chemistry.

  • David S. Glueck Homogeneous catalysis, asymmetric catalysis, sustainable energy 
  • Russell P. Hughes Organometallic mechanism and synthesis, CF bond activation, catalysis 
  • Ekaterina V. Pletneva Bioinorganic chemistry, redox reactivity and conformational dynamics of heme proteins 
  • Dean E. Wilcox Bioinorganic chemistry, thermodynamics of metal-protein interactions, metalloenzymes, nitric oxide biochemistry 

Experimental and Theoretical Physical Chemistry

John Winn's apparatus for studying molecules trapped in solid hydrogen, a quantum solid.

John Winn's apparatus for studying molecules trapped in solid hydrogen, a quantum solid.

Laser spectroscopy, NMR, statistical mechanics, quantum mechanics, and more.

  • Joseph J. BelBruno Experimental and computational study of clusters, sensors, nanomaterials 
  • Robert S. Cantor Biophysics of cell membranes, amphiphilic aggregates in solution 
  • Robert Ditchfield Theory of magnetic resonance parameters, theoretical studies of carbocation-pi complexation in the gas phase and in solution 
  • Jane E. G. Lipson Statistical mechanics of polymer melts, glasses, and blends.  Theory and simulation applied to problems of blend behavior, and glassy thin films and mixtures.
  • Dale F. Mierke Biophysical chemistry, high resolution NMR, peptide hormone structure and function
  • Ekaterina V. Pletneva Bioinorganic chemistry, redox reactivity and conformational dynamics of heme proteins 
  • John S. Winn Molecular spectroscopy and dynamics, molecular clusters, quantum solids, matrix isolation spectroscopy