Katherine A. Mirica

Assistant Professor of Chemistry

The research in the Mirica Group focuses on addressing global challenges in healthcare and environmental stewardship through innovations at the interfaces of Materials, Organic, and Analytical Chemistry.  The experimental strategy emphasizes molecular design and synthesis of responsive materials compatible with the unique demands of low-power, portable, affordable, easy-to-use electronic sensing devices.  An important aspect of research in the group is a feedback loop between fundamental and applied science, where the fundamental understanding of interactions of small molecules with responsive materials is used, probed, and refined in functional devices.  Materials and methods developed in the group may also be applicable to information storage, and energy storage, conversion, and catalysis.

Curriculum Vitae Personal Website Twitter LinkedIn
B.S. Boston College
Ph.D. Harvard University

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Selected Publications

21. Azzarelli, J. M.; Mirica, K. A.; Ravnsbæk, J. B.; Swager, T. M., “Wireless Gas Detection with a Smartphone via RF Communication” Proc. Nat. Acad. Sci. USA2014111, 18162–18166.

20. Frazier, K.; Mirica, K. A.; Walish, J. J.; Swager, T. M., “Drawing Sensors on Chips: Deposition of Carbon-Based Materials on Diverse Surfaces by Mechanical Abrasion” Lab Chip2014, 14, 4059–4066.

19. Mirica, K. A.; Azzarelli, J. M.; Weis, J. G.; Schnorr, J. M.; Swager, T. M., “Rapid Prototyping of Carbon-Based Chemiresistive Gas Sensors on Paper” Proc. Nat. Acad. Sci. USA2013110, E3265–E3270.

18. Mirica, K. A.; Weis, J. G.; Schnorr, J. M.; Esser, B.; Swager, T. M., “Mechanical Drawing of Gas Sensors on Paper” Angew. Chem. Int. Ed., 201251, 10740–10745.

17. Atkinson, M. B. J.; Bwambok, D. K.; Chen, J.; Chopade, P.; Thuo, M. M.; Mace, C. R.; Mirica, K. A.; Kumar, A. A.; Morin, S.; Lessing, J.; Shapiro, N. D.; Myerson, A.; Whitesides, G. M., “Using Magnetic Levitation to Separate Mixtures of Crystal Polymorphs”Angew. Chem. Int. Ed.201352, 10208–10211.

16. Bwambok, D. K.; Thuo, M. M.; Atkinson, M. B. J.; Mirica, K. A.; Shapiro, N. D.; Whitesides, G. M., “Paramagnetic Ionic Liquids for Density-Based Measurements Using Magnetic Levitation” Anal. Chem., 201385, 8442–8447.

15. Lockett, M.R.; Mirica, K. A.; Mace, C. R.; Blackledge, R.; Whitesides, G. M. “Analyzing Forensic Evidence Based on Density with Magnetic Levitation” J. Forensic Sci., 2013, 58, 40–45.

14. Shapiro, N. D.; Soh, S.; Mirica, K. A.; Whitesides, G. M. “Magnetic Levitation as a Platform for Competitive Protein-Ligand Binding Assays” Anal. Chem., 201284, 6166–6172.

13. Shapiro, N.D.; Mirica, K. A.; Soh, S.; Phillips, S. T.; Taran, O.; Mace, C. R.; Shevkoplyas, S. S.; Whitesides, G. M. “Measuring Binding of Protein to Gel-Bound Ligands Using Magnetic Levitation” J. Am. Chem. Soc.2012134, 5637–5646.

12. Vella, S. J.; Beattie, P.; Cademartiri, R.; Laromaine, A.; Martinez, A. W.; Phillips, S. T.; Mirica, K. A.; Whitesides, G. M. “Measuring Markers of Liver Function Using a Micropatterned Paper Device Designed for Blood from a Fingerstick” Anal. Chem.201284, 2883–2891.

11. Mirica, K. A.; Lockett, M.R.; Snyder, P. W.; Shapiro, N. D.; Mack, E. T.; Nam, S.; Whitesides, G. M. “Selective Precipitation and Purification of Monovalent Proteins Using Oligovalent Ligands and Ammonium Sulfate” Bioconjugate Chem.201223, 293–299.

10. Mecinović, J.; Snyder, P. W.; Mirica, K. A.; Bai, S.; Mack, E. T.; Kwant, R. L.; Moustakas, D. T.; Heroux, A.; Whitesides, G. M. “Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the ‘Hydrophobic Wall’ of Carbonic Anhydrase” J. Am. Chem. Soc.2011133, 14017–14026.

9. Ilievski, F.; Mirica, K. A.; Ellerbee, A. K.; Whitesides, G. M., “Templated Self-Assembly in Three Dimensions Using Magnetic Levitation” Soft Matter20117, 9113–9118.

8. Mirica, K. A.; Ilievski, F.; Ellerbee, A. K.; Shevkoplyas, S. S.; Whitesides, G. M., “Using Magnetic Levitation for Three Dimensional Self-Assembly”, Adv. Mater., 2011, 23, 4134–4140.

7. Lee, A.; Mirica, K. A.; Whitesides, G. M., “The Influence of Fluorocarbon and Hydrocarbon Acyl Groups at the Surface of Bovine Carbonic Anhydrase II on the Kinetics of Denaturation by Sodium Dodecyl Sulfate” J. Phys. Chem. B.2011115, 1199–1210.

6. Cheng, C.-M.; Martinez, A. W.; Gong, J.; Mace, C. R.; Phillips, S. T.; Carrilho, E.; Mirica, K. A.; Whitesides, G. M., “Paper-Based ELISA” Angew. Chem. Int. Ed., 201049, 4771–4774.

5. Reches, M.; Mirica, K. A.; Dasgupta, R.; Dickey, M. D.; Whitesides, G. M., “Thread as a Matrix for Biomedical Assays” ACS Appl. Mater. Interfaces20102, 1722–1728.

4. Mirica, K. A.; Phillips, S. T.; Mace, C. R.; Whitesides, G. M., “Magnetic Levitation in Analysis of Foods and Water” J. Agric. Food Chem.201058, 6565–6569.

3. Ellerbee, A. K.; Phillips, S. T.; Siegel, A.; Mirica, K. A.; Martinez, A. W.; Striehl, P.; Jain, N.; Prentiss, M.; and Whitesides, G. M., “Quantifying Colorimetric Assays in Paper-Based Microfluidic Devices by Measuring Transmittance Through Paper” Anal. Chem.,200981, 8447–8452.

2. Mirica, K. A.; Shevkoplyas, S. S.; Phillips, S. T.; Gupta, M., and Whitesides, G. M., “Measuring Densities of Solids and Liquids Using Magnetic Levitation: Fundamentals” J. Am. Chem. Soc.2009131, 10049–10058.

1. Mirica, K. A.; Phillips, S. T.; Shevkoplyas, S. S.; and Whitesides, G. M., “Using Magnetic Levitation to Distinguish Atomic-Level Differences in Chemical Composition of Polymers, and to Monitor Chemical Reactions on Solid Supports” J. Am. Chem. Soc.2008,130, 17678–17680.