Associate Professor of Chemistry
The Aprahamian group focuses on using modular, and tunable hydrazone-based building blocks in the development of structurally simple adaptive functional materials, e.g., molecular switches, fluorophores and sensors. For this purpose synthetic organic and organometallic chemistry is used in conjunction with advanced spectroscopic and computational methods.
Our interest in controlling molecular motion and converting it into mechanical work has driven us to the development of new hydrazone-based molecular switches that can be activated either chemically or photochemically. These novel systems are expected to form the basis of various molecular machines and motors.
The group is also developing new hydrazone-based fluorophores (i.e., solid-state BODIHY dyes, and blue-light emitting Triazolopyridinium salts) that can be used in sensing, bio-imaging, and OLED applications, among others.
X. Su, I. Aprahamian*, Hydrazone-Based Switches, Metallo-Assemblies and Sensors, Chem. Soc. Rev. 2014, 43, 1963–1981
Invited contribution to the special issue on “Supramolecular and Dynamic Covalent Reactivity”. Highlighted as an inside front cover.
X. Su, S. Voskian, R. P. Hughes, I. Aprahamian*, Manipulating liquid crystal properties using a pH activated hydrazone switch, Angew. Chem. Int. Ed. 2013, 52, 10734–10739.
Y. Yang, R. P. Hughes, I. Aprahamian*, Visible Light Switching of a BF2-Coordinated Azo Compound, J. Am. Chem. Soc. 2012, 134, 15221–15224.
Highlighted in Chemistry & Engineering News (September 17, 2012, p26).
D. Ray, J. T. Foy, R. P. Hughes, I. Aprahamian*, A switching cascade of hydrazone-based rotary switches through coordination-coupled proton relays, Nature Chem. 2012 , 4, 757-762.
Highlighted in the News and Views section of Nature Chemistry.
Y. Yang, X. Su, C. Carroll, I. Aprahamian*, Aggregation Induced Emission in BF2-Hydrazone (BODIHY) Complexes, Chem. Sci. 2012, 3, 610-613.
S. M. Landge, K. Tkatchouk, D. Benitez, D. A. Lanfranchi. M. Elhabiri, W. A. Goddard III, I. Aprahamian*, Isomerization Mechanism in Hydrazone-Based Rotary Switches: Lateral Shift, Rotation, or Tautomerization? J. Am. Chem. Soc. 2011, 133, 9812–9823.
X. Su, T. F. Robbins, I. Aprahamian*, Switching through Coordination-Coupled Proton Transfer, Angew. Chem. Int. Ed. 2011 , 50, 1841–1844.
S. M. Landge, I. Aprahamian*, pH Activated Configurational Rotary Switch: Controlling the E /Z Isomerization in Hydrazones, J. Am. Chem. Soc. 2009, 131, 18269–18271.