Ivan Aprahamian

Associate Professor of Chemistry

The Aprahamian group uses modular and tunable hydrazone-based building blocks to develop structurally simple adaptive functional materials, e.g., molecular switches, fluorophores and sensors. We rely on synthetic organic chemistry, in conjunction with advanced spectroscopic and computational methods in the design, fabrication, and characterization of the targeted systems .

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Our interest in controlling molecular motion and converting it into mechanical work has driven us to the development of new hydrazone-based molecular switches that can be activated either chemically or photochemically. These novel systems are expected to form the basis of various molecular machines and motors.

The group is also developing new hydrazone-based fluorophores (i.e., solid-state BODIHY dyes, and blue-light emitting Triazolopyridinium salts) that can be used in sensing, bio-imaging, and OLED applications, among others.

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B.Sc. The Hebrew University of Jerusalem
M.Sc. The Hebrew University of Jerusalem
Ph.D. The Hebrew University of Jerusalem

Selected Publications

H. Qian, S. Pramanik, I. Aprahamian, Photochromic Hydrazone Switches with Extremely Long Thermal Half-Lives, J. Am. Chem. Soc. 2017, 139, 9140–9143

I. Aprahamian, Hydrazone Switches and Things in Between, ChemCommun 2017, 53, 6674–6684

Highlighted as a front cover

H. Qian, Y.-Y. Wang, D.-S. Guo, I. Aprahamian, Controlling the Isomerization Rate of an Azo-BF2 Switch Using Aggregation, J. Am. Chem. Soc. 2017, 139, 1037–1040

H. Qian, M. E. Cousins, E. H. Horak, A. Wakefield, M. D. Liptak, I. Aprahamian, Suppression of Kasha’s Rule as a Mechanism for Fluorescent Molecular Rotors and Aggregation Induced Emission, Nature Chem. 2017, 9, 83–87.

Highlighted in ScienceDaily and PhysOrg and other news outlets.

 S. Pramanik, I. Aprahamian, Hydrazone Switch-Based Negative Feedback Loop, J. Am. Chem. Soc. 2016, 138, 15142–15145