Gordon Wayne Gribble
Professor of ChemistryThe Dartmouth Professor of Chemistry
Professor Gribble's research program covers several areas of organic chemistry, most of which involve synthesis, including novel indole chemistry, triterpenoid synthesis, DNA intercalation, and new synthetic methodology. Of prime interest is the synthesis of bis-acridines that act as DNA double intercalators, one of which is active against human glioblastoma cells. In the area of new synthetic methodology, Dr. Gribble and his students have discovered new chemistry of nitroindoles. A third area of research is the synthesis and biological activity of triterpenoids in the chemoprevention of cancer and other diseases related to inflammation. One of these synthetic triterpenoids, "bardoxolone methyl" has entered Phase 3 clinical trials for the treatment of chronic kidney disease in diabetes patients.
Dr. Gribble also has a deep interest in naturally occurring organohalogen compounds, and in the chemistry of wine and wine making.
“Potential DNA Bis-Intercalating Agents. Synthesis and Antitumor Activity of N,N-Methylenedi-4,1-cyclohexanediyl-bis(9-acridinamine) Isomers”; Gribble, G.W.; Mosher, M.D.; Jaycox, G.D.; Cory, M.; Fairley, T.A. Heterocycles, 2014, 88, 535-546.
"The Reaction of Arynes with Münchnones: Synthesis of Isoindoles and Azaisonindoles"; Lopchuk, J.M; Gribble, G. W. Tetrahedron Lett. 2014, 55, 2809-2812.
“Synthesis and Biological Evaluation of Amino Acid Methyl Ester Conjugates of 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid Against the Production of Nitric Oxide (NO)”; Onyango, E.O.; Fu, L.; Cao, M.; Liby, K.T.; Sporn, M.B.; Gribble, G.W. Bioorg. Med. Chem. Lett. 2014, 24, 532-534.
“Synthesis of a Dicyano Abietane, a Key Intermediate for the Antiinflammatory Agent ‘TBE-31’”; Onyango, E.O.; Fu, L.; Gribble, G.W. Organic Lett. 2014, 16, 322-324.
"Methyl 1-Benzyl-5-methyl-2,4-diphenyl-1H-pyrrole-3-carboxylate”; Lopchuk, J.M.; Gribble, G.W.; Jasinski, J.P. Acta Cryst. 2014, E70, o338-o339.
“Food Chemistry and Chemophobia”; Gribble, G.W. Food Security: The Science, Sociology and Economics of Food Production and Access to Food 2013, 5, 177-187.
"Synthesis and Diels-Alder Reactions of Pyrrolo[3,4-b]indoles. A Synthesis of 4-Acetamidocarbazoles and an Approach to the Antiostatins”; Pelkey, E.T.; Jiang, J.; Gribble, G.W. Indian J. Chem. 2013, 90, 1525-1536.
"Synthetic Approaches Towards the Marine Alkaloid Prenostodione”; Badenock, J.C.; Jordan, J.A.; Gribble, G.W. Tetrahedron Lett. 2013, 54, 2759-2762.
“Efficient and Scalable Synthesis of Bardoxolone Methyl (CDDO-Methyl Ester)”; Fu, L.; Gribble, G.W. Org. Lett. 2013, 15, 1672-1675
"A Short, Protecting Group-Free Total Synthesis of Bruceollines D, E, and J”; Lopchuk, J.M.; Green, I.; Badenock, J.C.; Gribble, G.W. Organic Lett. 2013, 15, 4485-4487.
"Manganese(III)-mediated Oxidative Radical Addition of Malonates to 2-Cyanoindole”; Lopchuk, J.M; Montgomery, W.L.; Jasinski, J.P.; Gorjifard, S.; Gribble, G.W. Tetrahedron Lett. 2013, 54, 6142-6145.
"What Controls the Regiochemistry in 1,3-Dipolar Cycloadditions of Münchnones with β-Nitrostyrenes?”; Lopchuk, J.M.; Hughes, R.P.; Gribble, G.W. Organic Lett. 2013, 15, 5218-5221.
Works in Progress
“Naturally Occurring Organohalogen Compounds — A Comprehensive Update”
“Indole Ring Synthesis: From Natural Products to Drug Discovery”
“Captain Aaron Gove Wilkins ’1942 – Iwo Jima Marine Corps Hero”