Title of project: Stereoselective Synthesis via Metallacycle-Mediated Bond Construction
Agency: The National Institutes of Health, National Institute of General Medical Sciences
Duration: four years
Broad description of research project: This research project aims to design and develop new stereoselective reactions in organic chemistry. Effort will be directed toward demonstrating that the advances emerging from such study can lead to the establishment of novel retrosynthetic relationships of great utility in complex molecule synthesis. In this way, our science aims to impact chemical synthesis at the strategic level. Efforts will also focus on demonstrating the ability to employ our new chemical reactions for the laboratory synthesis of rare natural products (and novel unnatural structural analogs) that are known to possess a range of medicinally relevant properties.